Stephen Castorino, MD

Weight Loss

Food you Should NEVER Eat trying to Lose Weight!

You need to know MUCH research goes on here at this facility to understand the mechanisms that underlie METABOLISM so that we can guide and treat YOU with a thorough understanding of why it is there are such PROFOUND differences in METABOLISM between one person and another.

After interviewing and treating THOUSANDS of people, it is now KNOWN why one person can eat 1200 calories and not lose weight while another can eat the same 1200 calories and lose like no other. Foods that alter YOUR METABOLIC profile absolutely MUST be AVOIDED even if you were Genetically bestowed with an ultra efficient metabolism (ie: Gain Weight on few Calories).

Other Food that you ingest can enhance your Metabolism.

#1 FOOD THAT IS NO-NO

FRUCTOSE: Yes the kind of SUGAR found in FRUIT. Thats the not so good news. We hear it all the time, eat plenty of FRUIT, Right? Turns out FRUCTOSE, because of its molecular structure, is preferentially processed to be stored easily as FAT.

GUT SYMBIOSIS: The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus.Manipulating and enhancing BUTYRATE in your gut and affect absorption of Calories and Satiation hormones GHRELIN and LEPTIN. These in turn ultimately affect your METABOLISM.

ON FRUCTOSE

Only a few years ago, most of us were under the misconception of assuming, we know fructose, glucose, have exactly the same number of calories per gram and they can be inter-converted instantly inside most cells, so why would it matter?

The answer is, it’s really important, Remarkably, because the liver metabolizes fructose and glucose in VERY different ways.

The BioMechanics of the story

FRUCTOSE_METABOLISM-271x300Sorry for getting a bit technical here but you need to understand this is NOT some gimmick or LOSE WEIGHT QUICK clinic. It gets more interesting as you read on, I promise.

In the liver, fructose bypasses the breakdown PHOSPHOFRUCTOKINASE (PFK) pathway, because it doesn’t need PFK; it gets phosphorylated at the one position directly, without phosphorylation of the six position first and, as a consequence, now becomes a substrate for aldolase, and it produces even higher levels of ATP and citrate that go on to make fatty acids. No matter how much you’ve eaten, you will still make more fat easier if you eat fructose.

There are two other things about fructose that make it different from glucose. One is that all the fructose you eat is cleared on its first pass through the liver. In other words, the liver scarfs up all the fructose and immediately converts it to fat, while glucose stays in the blood-stream for some period of time. That’s why we call starches hyperglycemic molecules; they keep glucose levels in your bloodstream high for a long time. That is good for the brain – the brain loves to eat glucose. It’s good for the muscle. But fructose doesn’t actually supply any energy to your brain at all, it doesn’t supply any energy to your muscle (thats the job of GLUCOSE); it only gets stored as fat.

But does it also mean that you get hungrier – you want more sugar if you’re using fructose rather than glucose?

Exactly. You would have to eat exactly twice as much Sucrose as starch to get the same amount of energy supplied to your muscle and brain. The brain realizes that, it keeps relaying a feedback so that the more sugar you eat, the more it wants you to eat. Hence the addiction to sweetness. That’s the dangerous thing about this molecule.

You might ask – well why did we evolve such a complicated system? Why does only the liver feed fructose straight into fat?

Evolutionarily, it’s quite clear why this happens. We have a symbiotic relationship with plants. Plants want to spread their seeds around, so they surround them with fructose. High-fructose material surrounding the seeds gets us and other animals to eat them and this craving of fructose makes us eat them a lot and we end up carrying their seeds around and spreading them. But at the same time, it gives us an advantage because those fruits ripen just at the end of the growing season, which generally means, in almost all environments, that you’re not going to have much to eat over the next few months.

So the best way to survive is to convert everything you eat at that time into fat. That is the long-term storage mechanism that allows you to survive until the next growing season. That’s why fructose was spectacular for us 10,000 years ago, getting us through these famines that we faced every year. But today we don’t have famines, we just have HIGH FRUCTOSE CORN SYRUP SODA, so we just get fat.

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

The altered gut microbiota stimulates differential production of SCFAs (like butyrate) that in turn promote GLP-1 secretion from L-cells to improve metabolic health and protect from obesity and diabetes. The studies proposed here will further justify the utility of probiotics, especially those that have the ability to positively influence the gut-SCFA-hormone axis, to prevent and treat obesity and diabetes. The possibility that dietary supplementation of probiotics can modify the gut flora and result in changes in the levels of short chain fatty acids that promote a release of hormones like GLP-1.

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

The gut microbiota may be a major player in maintaining human metabolism homeostasis. Although interest in humans has only recently developed, it becomes clear that we first need to unravel the underlying mechanisms in the causality of human obesity and T2DM in order to know how to influence these gut microbiota-driven processes. Despite our increasing knowledge on genetic pathways underlying human obesity and T2DM, specific data on the human gut microbiome are scarce.

Altering GUT Microbiota has Lasting Metabolic Consequences

If you are interested in Consultation to be Considered for Weight loss that involves Medically Managed Weight Loss.

If you have tried losing weight on your own, but your METABOLISM is not the same, losing any significant amount is not easy as it used to be. If you need to LOSE WEIGHT FAST, then you may have stumbled upon the incorrect place.

Our goal is to GIVE you with the tools combining better living through CHEMISTRY and KNOWLEDGE to INCREASE and MAINTAIN YOUR METABOLISM and SUSTAIN your RESULTS Long Term.

With time in research and knowledge we bring to the table there are many strategies available to suit each individual. With our guidance we hope that weight loss will be a whole lot less effort.

Medication Management so that If you don’t have to remind yourself to eat, we haven’t done our job. With so many pharmaceutical and dietary options available today, there should be no good reason for you to not SUCCEED with getting to your GOAL METABOLIC PROFILE.

A LITTLE BACKGROUND ON OUR TRENDS as a NATION:

Its clear by the national trends, WE NEED HELP losing weight! You are reading this because you must realize by now that living a more health quality of life means taking advantage of better living through chemistry.

obesity_trends_2010

This is truly ASTONISHING… we have no Self Control!

So what is Medically managed weight loss?

Essentially this would encompass supplements and/or Rx prescription medication that increase your metabolism and decrease your hunger in conjunction with high protein limited caloric intake regimen.

We research scientific literature to see what actually works and what is up and coming in the pipeline, so you dont have to sift through the MISINFORMATION Campaign that is littered throughout the internet. How can you know what to believe, what works and what doesn’t?

Several of the most effective treatments that we use, with dietary adjunct:

  • Combination Naltrexone & Bupropion for Obesity aka: CONTRAVE
  • Phentermine and various combination therapies
  • Bontril
  • Qsymia [Phentermine and Topamax]
  • Belviq [Locasarin]
  • HCG [Human Chorionic Gonadotropin] Sub Q Injections
  • GLP-1 Class [Byetta, Victoza, Bydureon, Symlin]
  • OTC Supplements: Systematic for supplements that actually WORK!

Diet vs. Exercise:

We have observed so many people say very similar things we notice trends. Literature supports the notion that is contrary to the believe that we will Run our Calories off. Exercise apparently accounts for 15% of weight loss at best. The other 85%… on the Intake end. Scientific research supports what we have observed.

Mind you, while some of these methods work for many people, we still take advantage of what science and chemistry has to offer. Some of the tried and proven medications are stimulants for appetite suppression; Phentermine, Bontril etc. Minimal addiction potential and surprisingly safe medication when taken and supervised responsibly. Others include, Bontril, Qsymia, as well as GLP-1 analogs such as Byetta, Victoza and Bydureon. In My Research Intermittent Fasting has MANY benefits that Science is only on the verge of discovering. Consider these most recent research articles:

Additional Resources

Diabetes
Weight Loss
Regenerative Medicine
Thyroid Disorders
Testosterone
Metabolic Disorders